Which factors are primarily known to affect tissue integrity?

The factors known to primarily affect tissue integrity include age, nutrition, hydration, circulation, and underlying health conditions.

Age plays a significant role, as the skin and other tissues undergo changes over time, making them more susceptible to injury and slower to heal. Nutrition is crucial; inadequate intake of vitamins and minerals can impair healing and tissue repair processes. Hydration is essential for maintaining skin elasticity and overall cell function. Circulation affects how well tissues receive oxygen and nutrients; compromised circulation can lead to ischemia and delayed healing. Lastly, underlying health conditions such as diabetes or vascular diseases can significantly impair the body's ability to maintain tissue integrity, often leading to poor wound healing or the development of ulcers.

The other options include important factors that affect health and well-being but do not directly emphasize the aspects that influence the actual integrity of tissues in the same primary manner. For instance, genetics and environmental factors can influence an individual’s overall health but are not as directly linked to immediate tissue integrity as the factors listed in the correct option.