What does a wound that is healing by secondary intention typically involve?

A wound healing by secondary intention typically involves the formation of granulation tissue. This process is significant because, in secondary intention healing, the wound is left open to heal naturally rather than being closed by surgical means. As the wound heals, granulation tissue, which is composed of new connective tissue and blood vessels, fills the wound space, providing a scaffold for further tissue development and ultimately leading to re-epithelialization.

This type of healing often occurs with larger or more complex wounds, where tissues are not easily approximated, and the body must work through a series of stages including inflammation, tissue formation, and remodeling. The characteristic of granulation tissue not only plays a crucial role in the healing process but also impacts the overall appearance and functional restoration of the tissue.

The other options do not accurately describe the processes involved in secondary intention healing.